Research

Over time, the continued use of photobiomodulation on the brain causes the brain to become a strengthened, upgraded organ as the cells begin to signal better and connectivity is repaired between the neurons. 

Current research has just scratched the surface as to advancing our understanding of how infrared light can be used to foster positive neurophysiological change. 

This is an exciting time for research, discovery in the field of digital neurotherapeutics, as it verges on discovering ever more profound answers and applications. We surely will gain greater understanding about the benefits of combining photobiomodulation and neurofeedback in remediating neuropsychiatric, neurodegenerative and neurodevelopmental disorders.

Below is a collection of the growing body of published research on clinical application of photobiomodulation.

Neuronic devices are not medical devices ​under any jurisdiction and are not intended to diagnose, treat, cure or prevent any disease. These statements have not been evaluated by the Food and Drug Administration. Neuronic is not providing any medical advice. We advise you to consult a medical professional and conduct your own independent research.

Alzheimer's Disease

Photobiomodulation is showing to be a promising new treatment strategy for Alzheimer's and other forms of neurodegenerative conditions including amnestic mild cognitive impairment (aMCI). Along with demonstrated clinical effectiveness, it represents a safe, inexpensive, sustainable treatment in both the clinical and at-home setting. Read more

Related Research

  • Photobiomodulation for Alzheimer's Disease: Has the Light Dawned? Michael R Hamblin, 2019. Link
  • Photobiomodulation with Near Infrared Light Helmet in a Pilot, Placebo Controlled Clinical Trial in Dementia Patients Testing Memory and Cognition Marvin H Berman 1, James P Halper 1, Trent W Nichols 2, H Jarrett 2, Alan Lundy 2, Jason H Huang, 2017. Link
  • Turning On Lights to Stop Neurodegeneration: The Potential of Near Infrared Light Therapy in Alzheimer's and Parkinson's Disease Daniel M Johnstone, Cécile Moro, Jonathan Stone, Alim-Louis Benabid, John Mitrofanis,  2016. Link
  • Shining light on the head: Photobiomodulation for brain disorders Michael R Hamblin 2016. Link
  • Synergistic photobiomodulation with 808-nm and 1064-nm lasers to reduce the β-amyloid neurotoxicity in the in vitro Alzheimer’s disease models Renlong Zhang, Ting Zhou, Soham Samanta, Ziyi Luo, Shaowei Li, Hao Xu and Junle Qu, 2022. Link
  • Transcranial Photobiomodulation of Clearance of Beta-Amyloid from the Mouse Brain: Effects on the Meningeal Lymphatic Drainage and Blood Oxygen Saturation of the Brain O. Semyachkina-Glushkovskaya, M. Klimova, T. Iskra, D. Bragin, A. Abdurashitov, A. Dubrovsky, A. Khorovodov, A. Terskov, I. Blokhina, N. Lezhnev, V. Vinnik, I. Agranovich, A. Mamedova,A. Shirokov,3 N. Navolokin,4 B. Khlebsov, V. Tuchin, and J. Kurths1,5,6 2021 Link

Long COVID-19

Current evidence suggests how the impact of COVID can be mitigated by 1070nm photobiomodulation. Our current efforts are to obtain support for trials directed at the underlying pathophysiological response as well as clinical trials with long-COVID subjects. We intend to study how repeated exposure to the 1070nm PBM may decrease the duration and intensity of long-COVID cognitive and physical symptoms as well as diminish the severity of post infection neurological injury. Read more

Related Research

  • Rationale for 1068 nm Photobiomodulation Therapy (PBMT) as a Novel, Non-Invasive Treatment for COVID-19 and Other Coronaviruses: Roles of NO and Hsp70, Lydia C. Kitchen,Marvin Berman, James Halper and Paul Chazot. 2022. Link
  • Probable positive effects of the photobiomodulation as an adjunctive treatment in COVID-19: A systematic review Marzieh Nejatifard, Sohrab Asefi, Raika Jamali, Michael R.Hamblin, Reza Fekrazade. 2020 Link
  • Influence of photobiomodulation therapy on the treatment of pulmonary inflammatory conditions and its impact on COVID-19 Daniela Bezerra Macedo 1, Carla Roberta Tim 1, Hueliton Wilian Kido 2 3, Juliana Bezerra Macedo 1, Cintia Cristina Santi Martignago 2, Ana Claudia Muniz Renno 2, Glauber Bezerra Macedo 3, Lívia Assis 4 2022 Link
  • Photobiomodulation therapy for treatment olfactory and taste dysfunction COVID‐19‐related: A case report Viviane Brocca de Souza; Ferreira, Laís Tatiane; Marcela Sene‐Fiorese; Garcia, Vanessa; Tiago Zuccolotto Rodrigues 2022 Link

Parkinson's Disease

PBM has been successfully used in animal models to reduce the signs of Parkinson’s Disease and to protect dopaminergic neurons. Moreover, recent clinical trials have shown that photobiomodulation can be an effective treatment method for individuals diagnosed with Parkinson’s disease, as it has shown to improve measures of mobility, cognition, dynamic balance and fine motor skill. Read more

Related Research

  • Treatment of Neurodegeneration: Integrating Photobiomodulation and Neurofeedback in Alzheimer's Dementia and Parkinson's: A Review, Marvin H Berman, Trent W Nichols, 2019 Link
  • Improvements in clinical signs of Parkinson’s disease using photobiomodulation: a prospective proof-of-concept study Liebert, Ann ; Bicknell, Brian ; Laakso, E-Liisa ; Heller, Gillian ; Jalilitabaei, Parastoo ; Tilley, Sharon ; Mitrofanis, John ; Kiat, Hosen, 2021 Link
  • Photobiomodulation in Parkinson's disease: A randomized controlled trial Santos, Luis; Olmo-Aguado, Susana del; Valenzuela, Pedro L.; Winge, Kristian; Iglesias-Soler, Eliseo; Argüelles-Luis, Juan; Álvarez-Valle, Samuel; Parcero-Iglesias, Guillermo J.; Fernández-Martínez, Ana; Lucia, Alejandro 2019 Link
  • Protocol for randomized controlled trial to evaluate the safety and feasibility of a novel helmet to deliver transcranial light emitting diodes photobiomodulation therapy to patients with Parkinson’s disease McGee, Claire; Liebert, Ann; Herkes, Geoffrey; Bicknell, Brian; Pang, Vincent; et al.  2022 Link

Autism

The use of photobiomodulation on people with Autism is being widely studied as a new alternative option for aiding some of the symptoms of Autism. Each year more research is being conducted and trials facilitated to learn more about the application of photobiomodulation on people with Autism. Read more

Related Research

  • Effects of Low-Level Laser Therapy in Autism Spectrum Disorder Gerry Leisman, Calixto Machado, Yanin Machado, Mauricio Chinchilla-Acosta. 2018  Link
  • Transcranial Photobiomodulation for the Treatment of Children with Autism Spectrum Disorder (ASD): A Retrospective Study Stefano Pallanti, Michele Di Ponzio, Eleonora Grassi, Gloria Vannini, Gilla Cauli 2022 Link
  • Efficacy of tPBM on ADHD symptoms and Executive Function Deficits in Adults with high-functioning Autism Spectrum Disorder Tolga Ceranoglu, Paolo Cassano, C Vutt Vater, Allison Green, Nina Dallenbach, Maura Disalvo, J Biederman, Gagan Joshi. 2022 Link

Healthy People - Optimal Performance

Photobiomodulation is not only something for those looking at alternative therapies. It can also be used on Healthy individuals to drive optimal performance, did you know Jack Dorsey used to stand under a near infrared light when working at Twitter? Read more

Related Research

  • The effect of photobiomodulation on the brain during wakefulness and sleep Moro, Cecile; Valverde, Audrey; Dole, Marjorie; Hoh Kam, Jaimie; Hamilton, Catherine; et al.  2022 Link
  • Effect of Transcranial Low-Level Light Therapy vs Sham Therapy Among Patients With Moderate Traumatic Brain Injury: A Randomized Clinical Trial Figueiro Longo, Maria Gabriela; Tan, Can Ozan; Chan, Suk-tak; Welt, Jonathan; Avesta, Arman; Ratai, Eva; Mercaldo, Nathaniel David; Yendiki, Anastasia; Namati, Jacqueline; Chico-Calero, Isabel; Parry, Blair A; Drake, Lynn; Anderson, Rox ; Rauch, Terry ; Diaz-Arrastia, Ramon; Lev, Michael; Lee, Jarone; Hamblin, Michael; Vakoc, Benjamin; Gupta, Rajiv 2020 Link
  • Improving executive function using transcranial infrared laser stimulation Nathaniel J. Blanco, W. Todd Maddox, F. Gonzalez-Lima 2017 Link
  • Transcranial infrared laser stimulation produces beneficial cognitive and emotional effects in humans D W Barrett 1, F Gonzalez-Lima 2013 Link

Traumatic Brain Injury

Traumatic brain injury (TBI) is a brain dysfunction caused by some type of trauma to the head, often resulting from sports injuries, road traffic accidents,  or blast injuries suffered in military conflict.

Did you know that each year in America roughly 1.5 million people have Traumatic Brain Injury, with only 1 out of 6 being hospitalized? Read more

Related Research

  • Traumatic Brain Injury: A Major Medical Problem That Could Be Treated Using Transcranial, Red/Near-Infrared LED Photobiomodulation Margaret A Naeser, Michael R Hamblin 3 2017 Link
  • Photobiomodulation for Traumatic Brain Injury and Stroke Michael R Hamblin. 2011 Link
  • Photobiomodulation using low-level laser therapy (LLLT) for patients with chronic traumatic brain injury: a randomized controlled trial study protocol Guilherme da Cruz Ribeiro Poiani, Ana Luiza Zaninotto, Ana Maria Costa Carneiro, Renato Amaro Zangaro, Afonso Shiguemi Inoue Salgado, Rodolfo Borges Parreira, Almir Ferreira de Andrade, Manoel Jacobsen Teixeira, and Wellingson Silva Paiva. 2018 Link

Neuropsychiatric Conditions -Depression and Anxiety

Many animal and human studies have reported the beneficial effects from the application of near-infrared PBM to improve the psychological status of patients with major depression and anxiety. 

Studies reviewed and described below provide strong evidence that suggest the mechanism of PBM (increasing mitochondrial activity and energy production, increasing regional blood flow) has a downstream effect of not only ATP production, but also potentially increases intercellular signalling and connectivity.

According to Hopkins Medicine, 9.5% of adults over the age of 18 suffer from depressive illness each year. Read more

Related Research

  • Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: a pilot study of 10 patients with major depression and anxiety Fredric Schiffer 1, Andrea L Johnston, Caitlin Ravichandran, Ann Polcari, Martin H Teicher, Robert H Webb, Michael R Hamblin 2009 Link
  • Transcranial photobiomodulation prevents anxiety and depression via changing serotonin and nitric oxide levels in brain of depression model mice: A study of three different doses of 810 nm laser Emad Eshaghi MSc,Saeed Sadigh-Eteghad PhD,Gisou Mohaddes PhD,Seyed Hossein Rasta PhD 2019 Link
  • Transcranial Photobiomodulation For The Management Of Depression: Current Perspectives Paula Askalsky and Dan V Iosifescu. 2019 Link
  • Photobiomodulation Therapy Ameliorates Glutamatergic Dysfunction in Mice with Chronic Unpredictable Mild Stress-Induced Depression Di Zhang,  Qi Shen, Xiaolei Wu, Da Xing, Stella Vieira. 2021 Link

Neuronic devices are not medical devices ​under any jurisdiction and are not intended to diagnose, treat, cure or prevent any disease. These statements have not been evaluated by the Food and Drug Administration. Neuronic is not providing any medical advice. We advise you to consult a medical professional and conduct your own independent research.

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