Photobiomodulation for

Alzheimer's

Alzheimer's disease is a devastating neurodegenerative disorder characterized by progressive cognitive impairment, memory loss, and behavioral changes.

While there is no known cure for Alzheimer's disease, recent research has suggested that photobiomodulation (PBM), also known as low-level light therapy or phototherapy, may have the potential to slow down or even reverse the progression of Alzheimer's.

Photobiomodulation (PBM) involves the use of low-level light energy to stimulate cellular function and promote healing. The brain is particularly sensitive to light, and research has shown that photobiomodulation (PBM) can improve brain function by increasing blood flow, reducing inflammation, and promoting the growth of new neurons and blood vessels.

Benefits of PBM in the pathophysiology of Alzheimer’s disease

Reduction of amyloid-beta protein levels
PBM can reduce the levels of amyloid-beta proteins in the brain, as demonstrated in several studies published in the Journal of Alzheimer's Disease in 2020 and 2018.

Stimulation of autophagy
PBM has been shown to stimulate autophagy in brain cells, which can help to clear up amyloid-beta proteins.

Neuroprotection
Photobiomodulation (PBM) has neuroprotective effects that can protect neurons from damage.

Anti-inflammatory effects
Photobiomodulation (PBM) has anti-inflammatory effects that can reduce inflammation in the brain.

Increased BDNF production
Photobiomodulation (PBM) can increase BDNF production, which can improve neuronal function.

Research

Advancing Brain Health: Neuronic at the Buck Institute of Ageing

Neuronic presented in California at the Buck Institute for Research on Ageing. Liam Pingree, Co-founder of Neuronic spoke alongside other industry leaders at the conference including Peter Diamandis MD, Eric Verdin MD, Leroy Hood MD, and many more.

Long Covid Treatment With Photobiomodulation Therapy: Does it work?

There are numerous approaches to improving brain health and functioning, among them are several techniques that are both non-invasive and non-pharmaceutical, these include light therapy also called photobiomodulation therapy (PBM), peripheral biofeedback (BFB) and brainwave biofeedback or neurofeedback (NFB).

Recap: 5th International Brain Stimulation Conference

Neuronic is going to be present with the Neuradiant 1070 at the 5th International Brain Stimulation Conference, a brain stimulation event in Lisbon, Portugal on February 19-22, 2023.

Health Optimisation Summit with the Neuradiant 1070

It was an honour to have the opportunity to engage with industry leaders and like-minded individuals, as well as to display our Neuradiant 1070 device at the Health Optimisation Summit.

Join Neuronic in the Collaboration In Aging: Transforming Senior Care in Denver, Colorado

Are you ready to revolutionize the way we support the aging journey? Neuronic, in collaboration with Mavericks of Senior Living, Colorado Placement & Referral Alliance (CoPRA), and Colorado Assisted Living Association (CALA), invites you to join us on September 27th and 28th in Denver, Colorado, for an event that promises to be a game-changer in the senior care industry.

Neuronic at the Biohacker Summit 2023: Optimizing Human Performance and Well-being

Are you ready to unlock the secrets of peak performance, healthy living, and well-being through cutting-edge science, nutrition, and technology? Neuronic is thrilled to be one of the exhibitors at the Biohacker Summit 2023, set to take place in Amsterdam on October 14-15, 2023.

Neuronic shines a spotlight on brain health at Leigh Steinberg Super Bowl Party

At Neuronic, we're passionate about revolutionizing brain health through cutting-edge technology. So when we were invited to sponsor the Brain Lounge at the Leigh Steinberg Super Bowl Party on February 10th, 2024, we knew it was a chance to showcase our commitment to enhancing cognitive well-being.

Neuronic Attended the PBM2024 in Westminster, London this August 22-25th as a Silver Sponsor.

Neuronic attending the PBM2024 in Westminster, London this August 22-25th as a Silver Sponsor. A successful few days where we got to listen to speakers presenting on the different photobiomodulation topics.

Neuronic Shines at Dave Asprey's 10th Annual Biohacking Conference in Dallas

This year, Neuronic represented by Co-founder Liam Pingree had the incredible opportunity to attend Dave Asprey's Biohacking Conference in Dallas, celebrating its 10th annual running.

Leading the way in Light therapy at ISNR 2024!

Neuronic was a vendor at the International Society for Neuroregulation and Research (ISNR) conference 2024 in Chicago, Illinois, USA.

PANS/PANDAS Awareness Day: Advocating for Evidence-Based Combination Therapies

Following PANS/PANDAS Awareness Day on October 9, we aim to continue efforts to raise awareness throughout this month. It is important to highlight the potential of innovative approaches for children suffering from these complex and debilitating conditions.

Can Infrared Light Help With Alzheimer's Disease? | Dr. Paul Chazot

Major brain diseases, like Alzheimer's or Parkinson's are affecting more and more people in the world. How can infrared light therapy help?

Light Therapy: The Future of Brain Health with Neuronic

Witness Jesse's remarkable journey in this video as he fights a blood infection that reached his aorta and caused a series of mini-strokes that caused emboli to enter his brain.

People with COVID-19 Brain Fog Benefit from Photobiomodulation Therapy

Discover how Photobiomodulation Therapy (PBM) utilizes the power of light to stimulate cellular function and restore cognitive clarity, offering new hope to individuals experiencing post-COVID cognitive challenges.

Alex Fergus: Red Light Therapy For Your Brain?

In this video, Alex Fergus provides an in-depth and honest review and introduction of our transcranial photobiomodulation device, the Neuradiant 1070, highlighting its key features and shedding light on its profound impact on brain health.

Alex Fergus interviews Neuronic's co-founder, Liam Pingree

Watch this interview between Alex Fergus, a health and technology enthusiast hailing from New Zealand, and Liam Pingree, the co-founder of Neuronic.

Medcram video featuring the Neuradiant 1070

In his latest video, Roger Seheult, MD of MedCram, explores the world of photobiomodulation devices and research, touching on topics like long COVID. Dr. Seheult, Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine, brings his expertise as an Associate Professor at the University of California, Riverside School of Medicine.

Innovative Neuronic debuts home-use brain-enhancing infrared device, surpassing $1.2 million in sales

The revolutionary device is designed to increase cellular energy and improve cognitive performance. Customers with neurodegenerative conditions and healthy individuals are thrilled with the results.

Neuradiant 1070 Demonstrates Success in Alleviating Long COVID Brain Fog & General Fatigue in Clinical Trial

A study that involved 14 subjects with Long COVID symptoms that included slowed thinking and reactions, mental fatigue, confusion and impaired verbal articulation.

Neuronic & SCU partner to develop next-gen neurotech for PBM guided by real-time brain activity

Neuronic and Santa Clara University (SCU) in Silicon Valley have announced a partnership to develop a research project to study photobiomodulation (PBM) guided by real-time brain activity, which will be led by Dr. Julia A. Scott and Dr. Sally Wood.

Neuronic Welcomes Light Therapy Experts to its Scientific Advisory Board

Neuronic is proud to announce the addition of two distinguished individuals to its Scientific Advisory Board.

Neuronic Introduces Revolutionary Helmet With Near-Infrared Light to Aid in Brain Function and Cognitive Impairment

The company's innovative LED-based photobiomodulation headset has produced positive results among users needing help with various conditions, including traumatic brain injuries.

Transform Your Clinical Practice with Neuronic's Photobiomodulation Device

As the landscape of therapeutic technologies evolves, the integration of light therapy devices into clinical practices is not just a trend but a revolution.

Autism Spectrum Disorder (ASD) and the Potential of Photobiomodulation

Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by challenges with social interaction, communication, and repetitive behaviors.

Does light therapy help improve sleep?

Sleep is an essential physiological process impacting numerous biological systems. Adequate sleep duration and quality are crucial for optimal brain function, cardiovascular health, cellular repair, and immune function.

Can Infrared Light Be A Weapon Against Cancer?

Cancer is tough, but science is finding clever ways to treat it, one of them being called photodynamic therapy (PDT). Photodynamic therapy, or PDT, is a treatment using a special drug activated by light to kill cancer cells.

Light on Sleep: How Photobiomodulation Assists the Brain's Waste Removal Process

Sleep isn't just a time to rest; it's super important for our everyday life and how we feel overall. It affects almost every type of tissue and system in the body – from the brain, heart, and lungs to metabolism, immune function, mood, and disease resistance.

What Are the Different Types of Brain Waves?

One of the big mysteries in the brain is something called 'brain waves.' These are like the brain's musical rhythms, and they play a big role in how we see, feel, and experience the world.

How to Use Light Therapy at Home: Maximizing its Benefits and Using It Safely

In our pursuit of maximum health and well-being, we frequently look for innovative and holistic ways to improve our everyday routines. Light therapy, a natural and non-invasive treatment, has emerged as a potential add-on therapy for promoting wellness.

Celebrating the Diversity of Human Brains on Neurodiversity Pride Day: Light Therapy for ADHD and Autism

As Neurodiversity Pride Day approaches on June 16th, we at Neuronic are proud to celebrate and support the diverse range of human brains.

Light Therapy for Improving Cognitive Functioning & Neurodegenerative Conditions

Neuroscientists have long been fascinated by the special intellectual capacities of the human brain.

Photobiomodulation for Alzheimer’s Disease: Has the Light Dawned?

Next to cancer, Alzheimer’s Disease (AD) and dementia is probably the most worrying health problem facing the western world today.

Can Transcranial Photobiomodulation Be Used To Modulate Neural Oscillations (tPBM)?

Transcranial photobiomodulation (tPBM) is a non-invasive brain stimulation technique that involves the use of near-infrared light to improve brain function.

Transcranial Photobiomodulation Enables Significant Changes in EEG Rhythms

A recent study demonstrated that prefrontal transcranial photobiomodulation (tPBM) with 1064-nm laser enables significant changes in EEG rhythms, but these changes might result from the laser-induced heat rather than transcranial photobiomodulation (tPBM).

Photobiomodulation at Different Wavelengths: 800nm, 850nm & 1064nm (Lasers vs LEDs)

An article entitled "Photobiomodulation at Different Wavelengths Boosts Mitochondrial Redox Metabolism and Hemoglobin Oxygenation: Lasers vs. Light-Emitting Diodes In Vivo" discusses photobiomodulation (PBM), a therapeutic approach that uses light to stimulate cell function, and how it can have different effects depending on the wavelength of the light used.

Short Term Memory Can Be Improved with 1064nm LED-based Transcranial Photobiomodulation (PBM)

A recent research from the University of Birmingham in the UK and the Beijing Normal University in China concluded that it's possible to improve short term memory with 1064nm LED-based transcranial photobiomodulation (PBM) in normal adults by around 10%.

Therapeutic Effects of Light Stimulation on Symptoms of Dementia

Dementia is a complex syndrome with various presentations depending on the underlying pathologies

3 Benefits of Neurofeedback Therapy

Neurofeedback therapy is a non-invasive procedure that uses brainwave feedback to help individuals regulate their own physiological and psychological states, providing real-time feedback about how the brain is functioning.

Exploring Light Therapy as an Alzheimer's Therapy Drug-Free Option

Alzheimer's disease is a huge challenge for modern medicine to treat, and it is made worse by factors like an ageing population, changing lifestyle preferences, and an increase in the number of affected individuals.

The Beneficial Effects of Photobiomodulation Therapy for Autism

According to the World Health Organization, a person with autism struggles with communication and social contact to a certain extent.

Light Therapy's Role in Addressing Long COVID: A Potential for 65 Million Affected

More than 65 million people worldwide struggle from Long COVID, which is characterized by agonizing symptoms such as heart palpitations, anxiety, extreme exhaustion, dizziness, and breathing difficulties.

Light therapy in Attention-Deficit Hyperactivity Disorder (ADHD)

Living with Attention-Deficit Hyperactivity Disorder (ADHD) can be challenging for many adults. Recent research explores the connection between ADHD symptoms, sleep activity patterns, and seasonal mood changes.

Four Years After COVID - The Role of Light Therapy in Brain Fog

Several people continue to experience persistent cognitive issues even after recovering from the initial phase of COVID-19, including with what we know as brain fog, a cognitive difficulty that have left researchers searching for solutions.

Navigating the Four Main Areas of the Brain for Optimal Brain Performance January 15, 2024

Have you ever wondered how our brain, the control center of our body, operates? Our brain has two halves, the right and the left. The right side manages the left part of our body, while the left side oversees the right.

Exploring the Neuradiant 1070’s Brainwave Protocols

Clients who have recently acquired the Neuradiant 1070 and professionals integrating it into their practice often seek guidance on the most effective protocols.

Unlocking Well-Being: Blue Zones & Light Therapy

You might have come across the term "Blue Zones" through the compelling lens of the Netflix documentary Live to 100: Secrets of the Blue Zones.

10 Effective Strategies for Improving Your Memory

Memory is a fundamental aspect of human cognition, shaping our understanding of the world and facilitating learning, problem-solving, and decision-making. Its significance transcends individual experiences, as memory collectively forms the basis of cultural knowledge and societal progress.

Memory Loss Treatment Options

Millions worldwide experience the complexities of memory loss. Its causes vary, ranging from aging and neurological diseases like Alzheimer's and dementia to traumatic brain injuries (TBI) and lifestyle factors.

Symptoms and causes of memory loss

Memory loss, a common concern affecting individuals across various age groups, presents in several forms and can significantly impact daily functioning and quality of life.

Unlocking Hope for Alzheimer's with Light Therapy

Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by a slow but steady decline in cognitive function. It represents around 70% of dementia cases globally and is designated by the World Health Organization (WHO) as a significant public health concern

The Science of Photobiomodulation on the Brain

Our brains are the most intricate and awe-inspiring organs in the human body. They control everything from our basic physiological functions like breathing and heart rate to our most complex thoughts, emotions, and memories.

Demystifying Dementia: Hope and New Approaches on the Horizon

Dementia, a condition often shrouded in fear and misunderstanding, affects millions globally. While there's currently no cure for dementia, significant advancements offer hope for the future.

Photobiomodulation for Parkinson's Disease

Parkinson's disease, the second most common neurodegenerative disease after Alzheimer's [1,2], casts a long shadow on millions of lives worldwide.

Why can't I see the lights inside my light therapy helmet?

At Neuronic, we're committed to providing brain photobiomodulation devices designed to enhance your well-being.One question we frequently encounter is, "Why can't I see the lights inside my light therapy helmet?" This might seem surprising, considering a lot of light therapy devices utilize visible red LEDs (620-750 nm).

How to book your free light therapy consultation

Neuronic offers a 30-minute complimentary consultation session to guide you through everything you need to know about using our Neuradiant 1070 device.

I just purchased the masterclass. How can I access it?

Congratulations on purchasing the Neuronic Masterclass! We're excited to have you join our learning community. This guide will walk you through accessing and starting your Masterclass on the Healthie platform.

The Role of the qEEG in Personalized Photobiomodulation Therapy

At Neuronic, we're dedicated to providing transcranial photobiomodulation (tPBM) devices that empower individuals to enhance their cognitive function, mood regulation, and sleep quality.

How to customize your Neuradiant 1070 and find your light therapy sweet spot

With the Neuradiant 1070, you have the freedom to customize your light experience based on your preferences and needs, enhancing it with your own research:

How long does each Neuradiant 1070 protocol last?

Wondering how long to use your Neuradiant 1070 for each program? We've got you covered! Here's a breakdown of the pre-set programs and their recommended durations:

What is the difference between red light and near-infrared light?

Unlocking the Mystery: A Comprehensive Guide to Understanding the Distinction between Red Light and Infrared Light

How soon can I expect results with transcranial photobiomodulation?

Brain photobiomodulation (PBM) is a rapidly evolving field with promising applications for brain health. By utilizing red or near-infrared light to stimulate cellular processes, photobiomodulation offers a non-invasive approach to potentially improve cognitive function, mood, sleep, and even manage neurological conditions.

What is the difference between 1070 nm vs 810 nm wavelengths?

Photobiomodulation (PBM) is an emerging non-invasive technique that uses specific wavelengths of light to interact with biological tissues, promoting beneficial effects such as enhanced cellular energy production, reduced inflammation, and improved blood flow.

Underestanding the GLOW Program: Embrace the Warmth and Maximize Your Experience October 30, 2024

Understanding how light therapy works for everyone can be tricky, while the concept is simple and we get near-infrared light from the sun applying it through various protocols can provide slight differences in the experience and results you feel.

Light Therapy for Sleep: A Powerful Solution for Better Rest and Improved Health

The understanding of sleep is a vast endeavor that is in its infancy. The difficulty in fully understanding sleep can be attributed to the incredible complexity of the human brain.

UFC legend Gray Maynard experiences remarkable cognitive improvement and increased productivity with Neuronic device

Partnering with Neuronic, Maynard underwent a comprehensive brain scan to assess the extent of his traumatic brain injury. Neuronic's team of experts then developed personalized protocols tailored to Maynard's specific needs to address his condition holistically.

Photobiomodulation: A Promising Light in Stroke Recovery

An ischemic stroke occurs when blood flow is lost to part of the brain. The brain cells in this region can be deprived of oxygen, and cell injury or cell death may follow.

Investigating Transcranial Photobiomodulation (tPBM) for Mold Exposure

Mold exposure can trigger a cascade of health concerns, ranging from respiratory problems to cognitive difficulties and fatigue.

How Transcranial Photobiomodulation Can Help Manage Epilepsy

Epilepsy is a complex neurological disorder characterized by recurrent seizures.

Exploring Transcranial Photobiomodulation for Aphasia

This article will explore two key concepts: aphasia, a language disorder, and transcranial photobiomodulation (tPBM), a therapeutic technique utilizing light.

Light therapy increases protective proteins in the brain & reduces harmful proteins linked to Alzheimer's Disease

Grillo, S. L. et al. (2013) explored the effects of light therapy on mice with Alzheimer's disease and found that it could potentially be a new treatment option as it increased the levels of certain proteins in the brain that help to protect against damage and reduce the build-up of harmful proteins that are associated with Alzheimer's disease.

Better cognitive function, sleep, and behavioral symptoms in people with Alzheimer’s Disease

Saltmarche et al. (2017) conducted a study on five patients with mild to moderately severe dementia that combined transcranial and intranasal PBM to treat specific areas of the brain associated with Alzheimer’s Disease. After 12 weeks of active treatment, the patients showed significant improvements in cognitive function, sleep, and behavioral symptoms, with no negative side effects.

Improvements in cognitive function, cerebral perfusion, and connectivity in people with dementia

Chao (2019) conducted a pilot trial on eight patients diagnosed with dementia who had a tPBM treatment at home. After 12 weeks, the tPBM group showed improvements in cognitive function, cerebral perfusion (blood flow to the brain), and connectivity within the brain's default-mode network.

Enhanced executive function, memory, and attention in people with dementia

Berman et al. (2017) conducted a small pilot double-blind, placebo-controlled trial on 11 subjects with dementia, using a helmet embedded with NIR PBM LEDs. The results showed improvements in executive function, memory, attention, and EEG measures.

Improved cerebral blood flow, reduction of dementia, and restoration of cognitive functions

Maksimovich, I. (2017) treated a large number of patients with AD in Moscow, Russia using an intravascular catheter approach to deliver light to the brain. The patients showed improvements in cerebral blood flow, reduction of dementia, and restoration of cognitive functions.

Better cognitive scores, olfactory function, quality of life, and caregiver stress in a person with cognitive decline

Salehpour et al. (2018) reported the treatment of a single case with cognitive decline and olfactory dysfunction, using three different wearable LED devices at home. The patient showed significant improvements in cognitive scores, olfactory function, quality of life, and caregiver stress.
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Researchers in Li-Huei Tsai's laboratory at the Picower Institute for Learning and Memory of MIT have also shown that disrupted gamma waves in the brains of mice with Alzheimer’s disease can be corrected by a unique non-invasive technique using flickering or pulsing light. The Neuradiant 1070 is the only product available in the market that offers customizable pulsing frequencies at 1070nm.

© Video copyright: Picower Institute for Learning and Memory

Animation: Sputnik Animation
Additional footage and music: Pond5


A study published in 2019 in the Journal of Alzheimer's Disease investigated the effects of PBM on cognitive function in mice with Alzheimer’s-like pathology. The study found that PBM improved cognitive function and reduced the levels of amyloid-beta plaques and tau protein, another hallmark of Alzheimer’s pathology.



Another study published in 2018 in the Journal of Photochemistry and Photobiology B: Biology investigated the effects of PBM on brain cells in vitro. The study found that PBM increased the production of ATP, reduced oxidative stress, and inflammation in brain cells.



Some studies have also suggested that photobiomodulation (PBM) may promote the growth of new neurons and synapses, which could help to repair damaged brain tissue and improve cognitive function. Clinical trials are currently underway to investigate the safety and efficacy of PBM for the treatment of Alzheimer’s in humans.



In conclusion, photobiomodulation (PBM) offers a promising potential for the treatment of Alzheimer's, and further research is needed to fully understand its therapeutic effects and the mechanisms by which it works.

References

1. Buendía D, Guncay T, Oyanedel M, Lemus M, Weinstein A, Ardiles ÁO, Marcos J, Fernandes A, Zângaro R, Muñoz P. The Transcranial Light Therapy Improves Synaptic Plasticity in the Alzheimer's Disease Mouse Model. Brain Sci. 2022 Sep 21;12(10):1272. doi: 10.3390/brainsci12101272. PMID: 36291206; PMCID: PMC9599908. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599908/

2. Lee TL, Ding Z, Chan AS. Can transcranial photobiomodulation improve cognitive function? A systematic review of human studies. Ageing Res Rev. 2023 Jan;83:101786. doi: 10.1016/j.arr.2022.101786. Epub 2022 Nov 9. PMID: 36371017. https://pubmed.ncbi.nlm.nih.gov/36371017/

3. Grillo, S. L., Duggett, N. A., Ennaceur, A., & Chazot, P. L. (2013). Non-invasive infra-red therapy (1072 nm) reduces β-amyloid protein levels in the brain of an Alzheimer's disease mouse model, TASTPM. Journal of photochemistry and photobiology. B, Biology, 123, 13–22. https://pubmed.ncbi.nlm.nih.gov/23603448/

4.Monteiro F, Carvalho Ó, Sousa N, Silva FS, Sotiropoulos I. Photobiomodulation and visual stimulation against cognitive decline and Alzheimer's disease pathology: A systematic review. Alzheimers Dement (N Y). 2022 Nov 25;8(1):e12249. doi: 10.1002/trc2.12249. PMID: 36447479; PMCID: PMC9695760. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695760/

5.Vrankic M, Vlahinić S, Šverko Z, Markovinović I. EEG-Validated Photobiomodulation Treatment of Dementia-Case Study. Sensors (Basel). 2022 Oct 5;22(19):7555. doi: 10.3390/s22197555. PMID: 36236654; PMCID: PMC9573554. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573554/

6.Salehpour F, Khademi M, Hamblin MR. Photobiomodulation Therapy for Dementia: A Systematic Review of Pre-Clinical and Clinical Studies. J Alzheimers Dis. 2021;83(4):1431-1452. doi: 10.3233/JAD-210029. PMID: 33935090. https://pubmed.ncbi.nlm.nih.gov/33935090/